Neutralization of Staphylococcus aureus Protein A Prevents Exacerbated Osteoclast Activity and Bone Loss during Osteomyelitis-Reference-Cited by-同舟云学术

Neutralization of Staphylococcus aureus Protein A Prevents Exacerbated Osteoclast Activity and Bone Loss during Osteomyelitis

Published:2023-01-24 Issue:1 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gehrke Ana-Katharina E.¹²,Mendoza-Bertelli Andrea³,Ledo Camila¹²,Gonzalez Cintia D.¹²,Noto Llana Mariángeles³⁴,Blanco Cintia¹,Sordelli Daniel O.³⁴,Putman Nicole E.⁵,Cassat James E.⁵⁶⁷^ORCID,Delpino María Victoria⁴⁸,Gómez Marisa I.¹²⁴^ORCID

Affiliation:

1. Centro de Estudios Biomédicos, Básicos, Aplicados y Desarrollo (CEBBAD), Departamento de Investigaciones Biomédicas y Biotecnológicas, Universidad Maimónides, Buenos Aires, Argentina

2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

3. Instituto de investigaciones en Microbiología y Parasitología Médica (IMPaM), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina

4. Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

5. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

6. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

7. Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee, USA

8. Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina

Abstract

Osteomyelitis caused by Staphylococcus aureus is an important and current health care problem worldwide. Treatment of this infection frequently fails not only due to the increasing incidence of antimicrobial-resistant isolates but also because of the ability of S. aureus to evade the immune system, adapt to the bone microenvironment, and persist within this tissue for decades.

Funder

Fundacion Cientifica Felipe Fiorellino

Burroughs Wellcome Fund and by the G. Harold and Leila Y. Mathers Charitable Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01140-22

Reference72 articles.