Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs

Author:

Herring Shawn1,Oda Jessica M.1,Wagoner Jessica1,Kirchmeier Delaney1,O’Connor Aidan1,Nelson Elizabeth A.2,Huang Qinfeng3,Liang Yuying3,DeWald Lisa Evans4,Johansen Lisa M.5,Glass Pamela J.4,Olinger Gene G.6,Ianevski Aleksandr7,Aittokallio Tero789,Paine Mary F.10ORCID,Fink Susan L.1,White Judith M.211ORCID,Polyak Stephen J.11213ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

2. Department of Cell Biology, University of Virginia, Charlottesville, Virginia, USA

3. Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, Minnesota, USA

4. Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

5. Horizon Discovery, Cambridge, Massachusetts, USA

6. MRIGlobal, Gaithersburg, Maryland, USA

7. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

8. Oslo Centre for Biostatistics and Epidemiology (OCBE), University of Oslo, Oslo, Norway

9. Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

10. Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA

11. Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

12. Department of Global Health, University of Washington, Seattle, Washington, USA

13. Department of Microbiology, University of Washington, Seattle, Washington, USA

Abstract

Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many approved drugs developed for other clinical indications inhibit EBOV and LASV and that combinations of these drugs provide synergistic suppression of EBOV, often by blocking discrete steps in virus entry.

Funder

HHS | National Institutes of Health

Washington Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference79 articles.

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