CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats-Reference-Cited by-同舟云学术

CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats

Published:2021-07-26 Issue:16 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Green Gia¹,Johnson Sara M.²³,Costello Heather²³,Brakel Kelsey¹,Harder Olivia¹,Oomens Antonius G.⁴,Peeples Mark E.²³^ORCID,Moulton Hong M.⁵,Niewiesk Stefan¹^ORCID

Affiliation:

1. College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA

2. Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

3. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

4. Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma, USA

5. Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA

Abstract

The knowledge about a virus receptor is useful to better understand the uptake of a virus into a cell and potentially develop antivirals directed against either the receptor molecule on the cell or the receptor-binding protein of the virus. Among a number of potential receptor proteins, human CX3CR1 has been demonstrated to act as a receptor for respiratory syncytial virus (RSV) on human epithelial cells in tissue culture.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00010-21

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