Potential Basis for Amphotericin B Resistance in Aspergillus terreus-Reference-Cited by-同舟云学术

Potential Basis for Amphotericin B Resistance in Aspergillus terreus

Published:2008-04 Issue:4 Volume:52 Page:1553-1555
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Blum Gerhard¹,Perkhofer Susanne¹,Haas Hubertus²,Schrettl Markus²,Würzner Reinhard¹,Dierich Manfred P.¹,Lass-Flörl Cornelia¹

Affiliation:

1. Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria

2. Division of Molecular Biology, Innsbruck Biocenter, Innsbruck Medical University, Innsbruck, Austria

Abstract

ABSTRACT This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus . The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus ( P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01280-07

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