Affiliation:
1. Eurofins Medinet, Inc., Herndon, Virginia
2. Wyeth Pharmaceuticals, Collegeville, Pennsylvania
Abstract
ABSTRACT
The current surveillance establishes the activity profile of tigecycline against recent clinical U.S. isolates of target pathogens. Findings from a distributed surveillance that utilized Etest yielded a tigecycline activity profile that varied from that observed in a separate centralized broth microdilution (BMD) surveillance (D. C. Draghi et al., Poster D-0701, 46th Intersci. Conf. Antimicrob. Agents Chemother., San Francisco, CA). Differences were noted among
Acinetobacter
spp. and
Serratia marcescens
and, to a lesser extent, with
Streptococcus pyogenes
. To address whether these differences were due to discordance in testing methodology or to variations among the analyzed populations, isolates from the current surveillance were concurrently tested by BMD and Etest. In all, 1,800
Staphylococcus aureus
, 259
S. pyogenes
, 226
Streptococcus pneumoniae
, 93
Enterococcus faecalis
, 1,356
Enterobacteriaceae
, and 227
Acinetobacter baumannii
strains were evaluated. Tigecycline had potent activity by BMD, with >99.6% susceptibility (%S) observed for all pathogens with interpretive criteria, excluding
Enterobacter cloacae
(98.3% S) and
E. faecalis
(86.0% S), and MIC
90
s ranged from 0.03 μg/ml (
S. pyogenes
/
S. pneumoniae
) to 1 μg/ml (
Enterobacteriaceae
/
A. baumannii
). Similar profiles were observed by Etest, with the exception of
A. baumannii
, although for most evaluated pathogens Etest MICs trended one doubling-dilution higher than BMD MICs. Major or very major errors were infrequent, and a high degree of essential agreement was observed, excluding
A. baumannii, S. marcescens
, and
S. pneumoniae
, for which ≥4-fold differences in MICs were observed for 29, 27.1, and 34% of the isolates, respectively. Further analysis regarding the suitability of the tigecycline Etest for testing
S. marcescens, Acinetobacter
spp., and
S. pneumoniae
is warranted.
Publisher
American Society for Microbiology
Cited by
52 articles.
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