Comparison of Activities of Broad-Spectrum β-Lactam Compounds against 1,128 Gram-Positive Cocci Recently Isolated in Cancer Treatment Centers-Reference-Cited by-同舟云学术

Comparison of Activities of Broad-Spectrum β-Lactam Compounds against 1,128 Gram-Positive Cocci Recently Isolated in Cancer Treatment Centers

Published:1999-04 Issue:4 Volume:43 Page:940-943
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Diekema Daniel J.¹,Coffman Stacy L.¹,Marshall Steven A.¹,Beach Mondell L.¹,Rolston Kenneth V. I.²,Jones Ronald N.¹

Affiliation:

1. Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa,1 and

2. Section of Infectious Diseases, University of Texas, M.D. Anderson Cancer Center, Houston, Texas2

Abstract

ABSTRACT We report the in vitro activities of broad-spectrum β-lactam antimicrobials tested against 1,128 gram-positive pathogens recently isolated from cancer patients. Cefepime and imipenem were more active than ceftazidime and ceftriaxone against these organisms. Only vancomycin demonstrated reliable activity against oxacillin-resistant staphylococci, Enterococcus spp., and Corynebacterium spp. The spectrum of gram-positive organisms against which cefepime and imipenem have activity provides an advantage over ceftazidime as empiric therapy for cancer patients, potentially reducing the need for the empiric addition of glycopeptides.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.4.940

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