Alterations in GyrA and ParC Associated with Fluoroquinolone Resistance in Enterococcus faecium-Reference-Cited by-同舟云学术

Alterations in GyrA and ParC Associated with Fluoroquinolone Resistance in Enterococcus faecium

Published:1999-04 Issue:4 Volume:43 Page:947-949
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

el Amin Nagwa¹,Jalal Shah¹,Wretlind Bengt¹

Affiliation:

1. Division of Clinical and Oral Bacteriology, Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Huddinge University Hospital, S-14186 Huddinge, Sweden

Abstract

ABSTRACT High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. One low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.4.947

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