Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes-Reference-Cited by-同舟云学术

Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes

Published:1999-04 Issue:4 Volume:43 Page:937-939
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hernández-Allés Santiago¹,Benedí Vicente J.¹,Martínez-Martínez Luis²,Pascual Álvaro²,Aguilar Alicia³,Tomás Juan M.³,Albertí Sebastián¹

Affiliation:

1. Área de Microbiologı́a, Departamento de Biologı́a, Universidad de las Islas Baleares and IMEDEA (CSIC-UIB), Palma de Mallorca,1

2. Departamento de Microbiologı́a, Universidad de Sevilla, Seville,2 and

3. Departamento de Microbiologı́a, Universidad de Barcelona, Barcelona,3 Spain

Abstract

ABSTRACT We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae . This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae , 4 presented ISs in their ompK36 gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.4.937

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