Application of UL144 Molecular Typing To Determine Epidemiology of Cytomegalovirus Infections in Preterm Infants

Author:

Stranska R.1,Schuurman R.1,Toet M.2,Verboon-Maciolek M.2,de Vries L. S.2,van Loon A. M.1

Affiliation:

1. Department of Virology, Eijkman-Winkler Centre, University Medical Centre, Utrecht, The Netherlands

2. Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands

Abstract

ABSTRACT Sequence analysis of the UL144 gene of human cytomegalovirus (CMV) was used to investigate the epidemiology of CMV infections in preterm infants. Nosocomial transmission of CMV from congenitally infected infant to preterm twins was excluded based on distinct molecular profiles of CMV strains. Indistinguishable molecular profiles between strains from the mother and the infant indicated postnatal acquisition of CMV through breastfeeding.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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