A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HgbA Vaccine Efficacy Trials-Reference-Cited by-同舟云学术

A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HgbA Vaccine Efficacy Trials

Published:2019-07 Issue:7 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Leduc Isabelle¹,Fortney Kate R.²,Janowicz Diane M.³,Zwickl Beth³,Ellinger Sheila³,Katz Barry P.⁴,Lin Huaiying⁵,Dong Qunfeng⁵,Spinola Stanley M.²³⁶

Affiliation:

1. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Department of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA

3. Department of Medicine, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA

4. Department of Biostatistics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA

5. Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA

6. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA

Abstract

Haemophilus ducreyi causes chancroid and is a major cause of cutaneous ulcers in children. Due to environmental reservoirs, both class I and class II H. ducreyi strains persist in cutaneous ulcer regions of endemicity following mass drug administration of azithromycin, suggesting the need for a vaccine.

Funder

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00112-19

Reference50 articles.

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