In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine-Reference-Cited by-同舟云学术

In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine

Published:1998-03 Issue:3 Volume:42 Page:540-544
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Domarle O.¹,Blampain G.¹,Agnaniet H.²,Nzadiyabi T.¹,Lebibi J.²,Brocard J.³,Maciejewski L.³,Biot C.³,Georges A. J.¹,Millet P.¹

Affiliation:

1. Centre International de Recherches Médicales de Franceville1 and

2. Université des Sciences et Techniques du Masuku,2 Franceville, Gabon, and

3. Université des Sciences et Technologies de Lille, Lille, France3

Abstract

ABSTRACT The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.3.540

Reference43 articles.

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