The Antibiotic Micrococcin Is a Potent Inhibitor of Growth and Protein Synthesis in the Malaria Parasite-Reference-Cited by-同舟云学术

The Antibiotic Micrococcin Is a Potent Inhibitor of Growth and Protein Synthesis in the Malaria Parasite

Published:1998-03 Issue:3 Volume:42 Page:715-716
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rogers M. John¹,Cundliffe Eric¹,McCutchan Thomas F.¹

Affiliation:

1. Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425

Abstract

ABSTRACT The antibiotic micrococcin is a potent growth inhibitor of the human malaria parasite Plasmodium falciparum , with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding levels of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.3.715

Reference20 articles.

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4. Secretory transport in Plasmodium.;Elmendorf H. G.;Parasitol. Today,1993

5. Effects of antibiotics on Plasmodium falciparum in vitro.;Geary T. G.;Am. J. Trop. Med. Hyg.,1983

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