Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching

Author:

Jeeva Subbiah1,Mir Sheema2,Velasquez Adrain3,Weathers Brandy A.3,Leka Aljona3,Wu Sharon3,Sevarany Ariga Tahmasian3,Mir Mohammad1

Affiliation:

1. Western University of Health Sciences, Pomona, California, USA

2. Applied BioCode, Santa Fe Springs, California, USA

3. College of Science, California State Polytechnic University, Pomona, California, USA

Abstract

Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. Hantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with mortality rates of 15% and 50%, respectively (1). Annually 150,000 to 200,000 cases of hantavirus infections are reported worldwide, for which there is no treatment at present. Cap snatching is an early event in the initiation of virus replication in infected hosts. Interruption in cap snatching will inhibit virus replication and will likely improve the prognosis of the hantavirus disease. Our studies provide mechanistic insight into the cap-snatching mechanism and demonstrate the requirement of a host cell factor for successful cap snatching. Identification of this host cell factor will reveal a novel therapeutic target for combating this viral illness.

Funder

Western University of Health Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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