Differential Splicing of Human Adenovirus 5 E1A RNA Expressed in cis versus in trans-Reference-Cited by-同舟云学术

Differential Splicing of Human Adenovirus 5 E1A RNA Expressed in cis versus in trans

Published:2021-02-24 Issue:6 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Graves Drayson¹,Akkerman Nikolas¹,Bachus Scott¹,Pelka Peter¹²^ORCID

Affiliation:

1. Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

2. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

Human adenovirus has become an important tool for medicine and research, and 293 cells and various similar cell lines are used extensively for virus production in situations where high viral yields are important. Such complementing cell lines are used for the production of viral vectors and vaccines, which often have deletions and replacements in various viral genes.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02081-20

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