Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 + and TIGIT + CD4 T Cells-Reference-Cited by-同舟云学术

Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 + and TIGIT + CD4 T Cells

Published:2019-05-15 Issue:10 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Llewellyn George N.¹,Seclén Eduardo¹,Wietgrefe Stephen²,Liu Siyu³,Chateau Morgan¹,Pei Hua³,Perkey Katherine²,Marsden Matthew D.⁴⁵,Hinkley Sarah J.⁶,Paschon David E.⁶,Holmes Michael C.⁶,Zack Jerome A.⁴⁵,Louie Stan G.³,Haase Ashley T.²,Cannon Paula M.¹

Affiliation:

1. Department of Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA

2. Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

3. School of Pharmacy, University of Southern California, Los Angeles, California, USA

4. Department of Medicine, University of California Los Angeles, Los Angeles, California, USA

5. Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA

6. Sangamo Therapeutics, Inc., Richmond, California, USA

Abstract

HIV-1 can establish latent infections that are not cleared by current antiretroviral drugs or the body’s immune responses and therefore represent a major barrier to curing HIV-infected individuals. However, the lack of expression of viral antigens on latently infected cells makes them difficult to identify or study. Here, we describe a humanized mouse model that can be used to detect latent but reactivatable HIV-1 in both untreated mice and those on ART and therefore provides a simple system with which to study the latent HIV-1 reservoir and the impact of interventions aimed at reducing it.

Funder

DHSC | National Institute for Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02086-18

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