Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border-Reference-Cited by-同舟云学术

Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Saito Makoto¹²³^ORCID,Yotyingaphiram Widi¹,Cargill Zillah¹⁴,Gilder Mary Ellen¹⁵,Min Aung Myat¹²,Phyo Aung Pyae¹²^ORCID,San Thi Dar¹,Poe Hilda¹,Chu Cindy¹²,White Nicholas J.²⁶,Nosten François¹²,McGready Rose¹²

Affiliation:

1. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand

2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

3. Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

4. Maidstone Hospital, Maidstone and Tunbridge Wells NHS Trust, Kent, United Kingdom

5. Department of Family Medicine, Chiang Mai University, Chiang Mai, Thailand

6. Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

Quinoline antimalarials cause drug-induced electrocardiograph QT prolongation, a potential risk factor for torsade de pointes. The effects of currently used antimalarials on the electrocardiogram (ECG) were assessed in pregnant women with malaria.

Funder

Clarendon Fund

Wellcome Trust

Holleypharm Pharmaceutical Company

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02473-20

Reference50 articles.

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4. Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base

5. World Health Organization. 2017. The cardiotoxicity of antimalarials. WHO Evidence Review Group Meeting Geneva Switzerland 13 to 14 October 2016. http://www.who.int/malaria/mpac/mpac-mar2017-erg-cardiotoxicity-report-session2.pdf.

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