Affiliation:
1. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
Abstract
ABSTRACT
Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (
P
< 0.05–0.005) from
Schistosoma mansoni
infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated,
r
= −0.621 and
r
= −0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.
Publisher
American Society for Microbiology
Subject
Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy
Cited by
36 articles.
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