Activity of Pure Streptovaricins and Fractionated Streptovaricin Complex Against Friend Virus-Reference-Cited by-同舟云学术

Activity of Pure Streptovaricins and Fractionated Streptovaricin Complex Against Friend Virus

Published:1975-03 Issue:3 Volume:7 Page:281-284
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Horoszewicz Julius S.¹,Rinehart Kenneth L.,Leong Susan S.,Carter William A.

Affiliation:

1. Department of Medical Viral Oncology and Department of Microbiology, Roswell Park Memorial Institute, Buffalo, New York 14203

Abstract

Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individual intact streptovaricins (A through G and J) show at least a 30-fold reduction in antiviral activity. These results further support the conclusion that the diversified biological properties of streptovaricin complex probably reside in different molecular structures.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.7.3.281

Reference15 articles.

1. Assay for Friend leukemia virus: rapid quantitative method based on enumeration of macroscopic spleen foci in mice;Axelrad A. A.;Virology,1964

2. Selective inhibition by streptovaricin of splenomegaly induced by Rauscher leukemia virus;Borden E. C.;Nature N. Biol.,1971

3. Streptovaricins inhibit RNAdependent DNA polymerase present in an oncogenic RNA virus;Brockman W. W.;Nature N. Biol.,1971

4. Byrd D. M. and W. A. Carter. 1973. Ansamycins: (B) streptovaricins p. 329-344. In W. A. Carter (ed.) Selective inhibitors of viral function. The Chemical Rubber Co. Press Cleveland Ohio.

5. Carter W. A. E. C. Borden W. W. Brockman D. Byrd W. Ligon F. Antosz and K. L. Rinehart Jr. 1974. Selective inhibition of RNA tumor virus function p. 303-310. In Molecular studies in viral neoplasia. The Williams and Wilkins Company Baltimore Md.

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