Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda-Reference-Cited by-同舟云学术

Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda

Published:2004-08 Issue:8 Volume:48 Page:3196-3199
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Krief Sabrina¹,Martin Marie-Thérèse¹,Grellier Philippe²,Kasenene John³,Sévenet Thierry¹

Affiliation:

1. Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex

2. USM 0504, Biologie Fonctionnelle des Protozoaires, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05, France

3. Makerere University, Biological Field Station, Fort Portal, Uganda

Abstract

ABSTRACT Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.8.3196-3199.2004

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