First Report of the Globally Disseminated IncX4 Plasmid Carrying themcr-1Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil

Abstract

ABSTRACTA colistin-resistantEscherichia colistrain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that theE. coliisolate belonged to the widespread sequence type (ST) 101 and harbored themcr-1gene on an IncX4 plasmid that was highly similar tomcr-1-bearing IncX4 plasmids that were recently identified inEnterobacteriaceaefrom food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of themcr-1gene.