Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital-Reference-Cited by-同舟云学术

Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital

Published:2018-02 Issue:2 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ramos Ana Carolina¹,Cayô Rodrigo¹,Carvalhaes Cecilia Godoy²,Jové Thomas³,da Silva Greice Pereira⁴,Sancho Fernanda Maciel Paschoin⁴,Chagas-Neto Thomas²,Medeiros Eduardo Alexandrino Servolo⁵,Gales Ana Cristina¹

Affiliation:

1. Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil

2. Universidade Federal de São Paulo (UNIFESP), Setor de Microbiologia-Laboratório Central, Hospital São Paulo, Division of Laboratory Medicine, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil

3. Université de Limoges, INSERM, Limoges, France

4. Hospital Estadual de Diadema, Associação Paulista para o Desenvolvimento da Medicina (SPDM), Diadema, Brazil

5. Universidade Federal de São Paulo (UNIFESP), Hospital Epidemiology Committee, Hospital São Paulo, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil

Abstract

ABSTRACT This study aimed to characterize multidrug-resistant Proteus mirabilis clones carrying a novel class 1 integron-borne bla IMP-1 . In 1359 was inserted into a large conjugative plasmid that also carried bla CTX-M-2 . The production of carbapenemases in Enterobacteriaceae that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01321-17

Reference23 articles.

1. The Pathogenic Potential of Proteus mirabilis Is Enhanced by Other Uropathogens during Polymicrobial Urinary Tract Infection

2. Necrotizing suppurative nephritis in a Japanese black feedlot steer due to Proteus mirabilis infection