Vertical Inheritance Facilitates Interspecies Diversification in Biosynthetic Gene Clusters and Specialized Metabolites

Author:

Chase Alexander B.1ORCID,Sweeney Douglas1ORCID,Muskat Mitchell N.1ORCID,Guillén-Matus Dulce G.1ORCID,Jensen Paul R.12ORCID

Affiliation:

1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA

2. Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA

Abstract

Microbial natural products are traditionally exploited for their pharmaceutical potential, yet our understanding of the evolutionary processes driving BGC evolution and compound diversification remains poorly developed. While HGT is recognized as an integral driver of BGC distributions, we find that the effects of vertical inheritance on BGC diversification had direct implications for species-level specialized metabolite production.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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