Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants

Author:

Crits-Christoph Alexander12,Kantor Rose S.3,Olm Matthew R.4,Whitney Oscar N.5,Al-Shayeb Basem12,Lou Yue Clare12,Flamholz Avi5,Kennedy Lauren C.3,Greenwald Hannah3,Hinkle Adrian3,Hetzel Jonathan6,Spitzer Sara6,Koble Jeffery6,Tan Asako6,Hyde Fred7,Schroth Gary6,Kuersten Scott7,Banfield Jillian F.28910,Nelson Kara L.23

Affiliation:

1. Department of Plant and Microbial Biology, University of California, Berkeley, California, USA

2. Innovative Genomics Institute, Berkeley, California, USA

3. Department of Civil and Environmental Engineering, University of California, Berkeley, California, USA

4. Department of Microbiology and Immunology, Stanford University, Stanford, California, USA

5. Department of Molecular and Cell Biology, University of California, Berkeley, California, USA

6. Illumina, San Diego, California, USA

7. Illumina, Madison, Wisconsin, USA

8. Department of Environmental Science, Policy, and Management, University of California, Berkeley, California, USA

9. Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA

10. Chan Zuckerberg Biohub, San Francisco, California, USA

Abstract

Viral genome sequencing has guided our understanding of the spread and extent of genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. SARS-CoV-2 viral genomes are usually sequenced from nasopharyngeal swabs of individual patients to track viral spread.

Funder

Innovative Genomics Institute

Center for Information Technology Research in the Interest of Society

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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