ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin-Reference-Cited by-同舟云学术

ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bordeleau Emily¹,Stogios Peter J.²³,Evdokimova Elena²³,Koteva Kalinka¹,Savchenko Alexei²³⁴^ORCID,Wright Gerard D.¹^ORCID

Affiliation:

1. David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

2. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

3. Center for Structural Genomics of Infectious Diseases (CSGID), University of Calgary, Calgary, Alberta, Canada

4. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

Abstract

Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it has become an attractive candidate to repurpose in the fight against multidrug-resistant pathogens prioritized by the World Health Organization.

Funder

Ontario Research Fund

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health and Human Services

Canada Research Chairs

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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