Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death

Author:

Bhaskar Meenakshi1,Mukherjee Sriparna1,Basu Anirban1ORCID

Affiliation:

1. National Brain Research Centre, Manesar, Haryana, India

Abstract

Neurotropic viral infections are an increasingly common cause of immediate or delayed neuropsychiatric sequelae, cognitive impairment, and movement disorders or, in severe cases, death. Given the highest reported disability-adjusted life years and mortality rate worldwide, a better understanding of molecular mechanisms for underlying clinical manifestations like AFP will help in development of more effective tools for therapeutic solutions.

Funder

Science and Engineering Research Board (SERB), Ministry of Science and Technology, Government of India

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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