Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum-Reference-Cited by-同舟云学术

Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Evans Heather M.¹,Schultz Destiny F.¹,Boiman Adam J.¹,McKell Melanie C.²³⁴,Qualls Joseph E.²³⁴,Deepe George S.¹^ORCID

Affiliation:

1. Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

2. Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

4. Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Abstract

Histoplasma capsulatum and related Histoplasma species are intracellular fungal pathogens endemic to broad regions of the globe, including the Americas, Africa, and Asia. While most infections resolve with mild or no symptoms, failure of the host to control fungal growth produces severe disease.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02710-21

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