Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1-Reference-Cited by-同舟云学术

Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sun Zhizeng¹,Palzkill Timothy¹^ORCID

Affiliation:

1. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA

Abstract

Polymyxin antibiotics are used as last-line antibiotics in treating infections caused by multidrug-resistant pathogens. However, widespread use of polymyxins has led to the emergence of resistance.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02776-21

Reference42 articles.

1. Studies on Polymyxin: Isolation and Identification of Bacillus polymyxa and Differentiation of Polymyxin from Certain Known Antibiotics

2. Structure−Activity Relationships of Polymyxin Antibiotics

3. Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

4. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

5. Agents of Last Resort

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