Affiliation:
1. Division of Arthritis, Department of Internal Medicine and Department of Microbiology, University of Utah College of Medicine, Salt Lake City, Utah 84112
Abstract
Concentrated broth constituents markedly enhanced the development of abscesses after subcutaneous injection of
Mycoplasma arthritidis
. Under appropriate conditions, both virulent and avirulent strains of
M. arthritidis
produced toxic effects in mice, as detected by the development of necrotic abscesses and death of the animals. The treatment of mice at birth with
M. arthritidis
antigens rendered the animals more susceptible to infection with
M. arthritidis
later in life, as evidenced by increased arthritis after intravenous injection. The injection of
M. arthritidis
into pregnant mice resulted in a high incidence of abortions. Comparative studies using different mouse strains showed that DBA mice were the most susceptible and BALB/c and C57BL mice were the most resistant to infection by
M. arthritidis
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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