False-Positive Results of Enzyme Immunoassays for Human Immunodeficiency Virus in Patients with Uncomplicated Malaria-Reference-Cited by-同舟云学术

False-Positive Results of Enzyme Immunoassays for Human Immunodeficiency Virus in Patients with Uncomplicated Malaria

Published:2006-08 Issue:8 Volume:44 Page:3021-3024
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Gasasira Anne F.¹,Dorsey Grant²,Kamya Moses R.¹,Havlir Diane²,Kiggundu Moses¹,Rosenthal Philip J.²,Charlebois Edwin D.²

Affiliation:

1. Department of Medicine, Makerere University Medical School, Kampala, Uganda

2. Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California

Abstract

ABSTRACT Malaria may impact upon human immunodeficiency virus (HIV) test results. We evaluated two HIV enzyme immunoassays (EIAs) by testing 1,965 Ugandans with malaria. We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02207-05

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