The poly(C) region affects progression of encephalomyocarditis virus infection in Langerhans' islets but not in the myocardium-Reference-Cited by-同舟云学术

The poly(C) region affects progression of encephalomyocarditis virus infection in Langerhans' islets but not in the myocardium

Published:1997-05 Issue:5 Volume:71 Page:4145-4149
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zimmermann A¹,Botta A¹,Arnold G¹,Eggers H J¹,Nelsen-Salz B¹

Affiliation:

1. Institut für Virologie der Universität zu Köln, Cologne, Germany.

Abstract

The diabetogenic variant PV2 of encephalomyocarditis virus was cloned, and three recombinants differing in their 5' poly(C) tracts were analyzed. It is shown that the poly(C) region is not essential for infectivity in mice but does influence the virus load and degree of pathological lesions within the Langerhans' islets but not in the myocardium.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.71.5.4145-4149.1997

Reference22 articles.

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4. Poly(C) in animal viral RNAs;Brown F.;Nature (London),1974

5. Relationship of interferoninducing particle phenotype to encephalomyocarditis virus-induced diabetes mellitus;Cohen S. H.;Infect. Immun.,1983

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