Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model-Reference-Cited by-同舟云学术

Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Suerbaum Sebastian¹²³⁴,Coombs Nina¹,Patel Lubna²,Pscheniza Dimitri¹,Rox Katharina⁵³,Falk Christine⁶,Gruber Achim D.⁷,Kershaw Olivia⁷,Chhatwal Patrick¹³,Brönstrup Mark⁵³^ORCID,Bilitewski Ursula⁵³,Josenhans Christine¹²³⁴

Affiliation:

1. Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany

2. Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Munich, Germany

3. German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany

4. German Center for Infection Research (DZIF), partner site Munich, Munich, Germany

5. Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

6. Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany

7. Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany

Abstract

Helicobacter pylori is one of the most prevalent bacterial pathogens, inflicting hundreds of thousands of peptic ulcers and gastric cancers to patients every year. Antibacterial treatment of H. pylori is complicated due to the need of combining multiple antibiotics, entailing serious side effects and increasing selection for antibiotic resistance.

Funder

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03755-21

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2. Helicobacter pylori and gastric adenocarcinoma

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