The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters

Author:

Shytaj Iart Luca12ORCID,Fares Mohamed34,Gallucci Lara1,Lucic Bojana15,Tolba Mahmoud M.6,Zimmermann Liv78,Adler Julia M.9,Xing Na9,Bushe Judith10,Gruber Achim D.10,Ambiel Ina1,Taha Ayoub Ahmed11,Cortese Mirko12ORCID,Neufeldt Christopher J.1213,Stolp Bettina1,Sobhy Mohamed Hossam11,Fathy Moustafa1415,Zhao Min16,Laketa Vibor57,Diaz Ricardo Sobhie2ORCID,Sutton Richard E.16,Chlanda Petr78,Boulant Steeve717ORCID,Bartenschlager Ralf512ORCID,Stanifer Megan L.1217,Fackler Oliver T.15ORCID,Trimpert Jakob9,Savarino Andrea18,Lusic Marina15

Affiliation:

1. Department of Infectious Diseases, Integrative Virology, Heidelberg University, Heidelberg, Germany

2. Federal University of São Paulo, Infectious Diseases Department, São Paulo, Brazil

3. Department of Hydrobiology, Veterinary Research Division, National Research Centre, Cairo, Egypt

4. Center for Informatics Science (CIS), Nile University, Sheikh Zayed City, Giza, Egypt

5. German Center for Infection Research (DZIF), Heidelberg, Germany

6. Pharmaceutical Division, Ministry of Health and Population, Faiyum, Egypt

7. Department of Infectious Diseases, Virology, CIID, Heidelberg University Hospital, Heidelberg, Germany

8. Schaller Research Groups, Center of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany

9. Institut für Virologie, Freie Universität Berlin, Berlin, Germany

10. Institute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany

11. Biomolecular Simulation Center, Department of Pharmaceutical Chemistry, Heliopolis University, Cairo, Egypt

12. Department of Infectious Diseases, Molecular Virology, CIID, Heidelberg University, Heidelberg, Germany

13. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

14. Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

15. Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

16. Yale School of Medicine, Department of Internal Medicine, Section of Infectious Diseases, New Haven, Connecticut, USA

17. Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA

18. Department of Infectious Diseases, Italian Institute of Health, Rome, Italy

Abstract

The lack of effective antiviral treatments against SARS-CoV-2 is a significant limitation in the fight against the COVID-19 pandemic. Single-drug regimens have so far yielded limited results, indicating that combinations of antivirals might be required, as previously seen for other RNA viruses.

Funder

MWK Baden Wuerttemberg

Helmoltz Association Initative and Networking Fund

Chica and Heinz Schaller Foundation

Deutsche Forschungsgemeinschaft

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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