Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair-Reference-Cited by-同舟云学术

Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gruber Charley C.¹,Babu Vignesh M. P.¹,Livingston Kamren¹,Joisher Heer¹,Walker Graham C.¹^ORCID

Affiliation:

1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Abstract

Bacterial cell death is a poorly understood process. The generation of reactive oxygen species (ROS) is an apparently common response to challenges by a wide variety of lethal stresses, including bactericidal antibiotics.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Environmental Health Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03756-21

Reference71 articles.

1. Unraveling the Physiological Complexities of Antibiotic Lethality

2. A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics