Inhibition of Protein <i>N-</i> Glycosylation Blocks SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Casas-Sanchez Aitor¹²^ORCID,Romero-Ramirez Alessandra¹²,Hargreaves Eleanor³,Ellis Cameron C.⁴,Grajeda Brian I.⁴,Estevao Igor L.⁴,Patterson Edward I.¹²⁵^ORCID,Hughes Grant L.¹²^ORCID,Almeida Igor C.⁴,Zech Tobias³,Acosta-Serrano Álvaro¹²^ORCID

Affiliation:

1. Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

2. Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

3. Department of Molecular and Cellular Physiology, University of Liverpool, Liverpool, United Kingdom

4. Department of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas, USA

5. Department of Biological Sciences, Brock University, St. Catharines, Canada

Abstract

The coronavirus SARS-CoV-2 uses its spike surface proteins to infect human cells. Spike proteins are heavily modified with several N -glycans, which are predicted to modulate their function.

Funder

HHS | NIH | National Institute on Minority Health and Health Disparities

HHS | National Institutes of Health

Liverpool School of Tropical Medicine

National Institute for Health Research

Royal Society

UK Research and Innovation

UKRI | Biotechnology and Biological Sciences Research Council

UKRI | Engineering and Physical Sciences Research Council

Publisher

American Society for Microbiology

Subject