Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis-Reference-Cited by-同舟云学术

Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ciaston Izabela¹,Budziaszek Joanna¹,Satala Dorota²,Potempa Barbara³,Fuchs Andrew³,Rapala-Kozik Maria²,Mizgalska Danuta¹,Dobosz Ewelina¹,Lamont Richard J.³^ORCID,Potempa Jan¹³,Koziel Joanna¹^ORCID

Affiliation:

1. Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

2. Department of Comparative Biochemistry and Bioanalytic, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

3. Department of Oral Immunity and Infectious Diseases, University of Louisville School of Dentistry, University of Louisville, Louisville, Kentucky, USA

Abstract

Gingipain cysteine proteases are essential virulence factors of Porphyromonas gingivalis , an oral bacterium implicated in development of periodontitis. Gingipains diffusing from anaerobic periodontal pockets lose proteolytic activity in the oxygenated environment of gingival tissues.

Funder

National Science Center

US National Institute of Health

US national Institute of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03787-21

Reference51 articles.

1. The role of the microbiota in periodontal disease