Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis

Author:

Flynn Alexander F.1ORCID,Taylor Rebekah T.2ORCID,Pazgier Marzena E.3ORCID,Bennuru Sasisekhar4,Lindrose Alyssa R.15,Sterling Spencer L.1,Morris C. Paul6,Gleeson Brynna I.1,Maugel Tim K.7,Nutman Thomas B.4ORCID,Mitre Edward1ORCID

Affiliation:

1. Department of Microbiology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

2. Department of Biology, Frostburg State University, Frostburg, Maryland, USA

3. Department of Medicine, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

4. National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA

5. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA

6. Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland, USA

7. Laboratory for Biological Ultrastructure, Department of Biology, University of Maryland, Silver Spring, Maryland, USA

Abstract

Brugia malayi is a parasitic nematode that can cause lymphatic filariasis, a debilitating disease prevalent in tropical and subtropical countries. Significant progress has been made toward eliminating the disease.

Funder

DOD | Uniformed Services University of the Health Sciences

USU Center for Global Health Engagement

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference74 articles.

1. Adaptive immune activation: glycosylation does matter

2. Progress and Impact of 13 Years of the Global Programme to Eliminate Lymphatic Filariasis on Reducing the Burden of Filarial Disease

3. Institute for Health Metrics and Evaluation. 2021. Global burden of disease study 2019 results tool. http://ghdx.healthdata.org/gbd-results-tool. Accessed 19 June 2021.

4. WHO. 2016. Global programme to eliminate lymphatic filariasis. http://www.who.int/lymphatic_filariasis/disease/en/. Accessed 2 May 2021.

5. WHO. 2020. Ending the neglect to attain the sustainable development goals: a road map for neglected tropical diseases 2021–2030. Overview. World Health Organization, Geneva, Switzerland.

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