Inability To Make a Premortem Diagnosis of Acanthamoeba Species Infection in a Patient with Fatal Granulomatous Amebic Encephalitis

Author:

Bloch Karen C.1,Schuster Frederick L.2

Affiliation:

1. Departments of Medicine and Preventive Medicine, Vanderbilt University, Nashville, Tennessee

2. California Department of Health Services, Richmond, California

Abstract

ABSTRACT Granulomatous amebic encephalitis (GAE), an infection of immunocompromised hosts, is almost uniformly fatal. A case of GAE in a patient who failed to mount a serologic response to Acanthamoeba polyphaga is presented. Although Acanthamoeba polyphaga that is sensitive to multiple antimicrobials grew from brain tissue, an inability to make a premortem diagnosis precluded therapy.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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