Affiliation:
1. Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201
2. University of Louvain, Faculty of Medicine, Microbiology Unit, B-1200 Brussels, Belgium
Abstract
ABSTRACT
The intra- and interspecies genetic relationships of 58 strains representing all currently known species of the genus
Yersinia
were examined by multilocus sequence typing (MLST), using sequence data from 16S RNA,
glnA
,
gyrB
,
recA
, and Y-HSP60 loci.
Yersinia
aldovae
,
Y. bercovieri
,
Y. intermedia
,
Y. pestis
,
Y. pseudotuberculosis
,
Y. rohdei
, and
Y. ruckeri
were genetically more homogeneous than were
Y. enterocolitica
,
Y. frederiksenii
,
Y. kristensenii
, and
Y. mollaretii
. The MLST data concerning the genetic relatedness within and among various species of
Yersinia
support the idea that
Y. pestis
and
Y. pseudotuberculosis
are two lineages within the same species rather than two distinct species.
Y. ruckeri
is the genetically most distant species within the genus. There was evidence of O-antigen switching and genetic recombination within and among various species of
Yersinia
. The genetic relatedness data obtained by MLST of the four housekeeping genes and 16S RNA agreed in most, but not all, instances. MLST was better suited for determining genetic relatedness among yersiniae than was 16S RNA analysis. Some strains of
Y. frederiksenii
and
Y. kristensenii
are genetically less related to other strains within those species, compared to strains of all other species within the genus. The taxonomic standing of these strains should be further examined because they may represent currently unrecognized
Yersinia
species.
Publisher
American Society for Microbiology
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