Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits-Reference-Cited by-同舟云学术

Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Petraitiene Ruta¹^ORCID,Petraitis Vidmantas¹,Maung Bo Bo Win¹,Mansbach Robert S.²,Hodges Michael R.³,Finkelman Malcolm A.⁴,Shaw Karen Joy⁵,Walsh Thomas J.¹⁶⁷

Affiliation:

1. Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, USA

2. Mansbach Consulting, LLC, San Diego, California, USA

3. Amplyx Pharmaceuticals, Inc., San Diego, California, USA

4. Associates of Cape Cod, Inc., East Falmouth, Massachusetts, USA

5. Hearts Consulting Group, LLC, Poway, California, USA

6. Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA

7. Department of Microbiology & Immunology, Weill Cornell Medicine, New York, New York, USA

Abstract

Candida endophthalmitis is a serious sight-threatening complication of candidemia that may occur before or during antifungal therapy. Hematogenous Candida meningoencephalitis (HCME) is also a serious manifestation of disseminated candidiasis in premature infants, immunosuppressed children, and immunocompromised adults.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01795-20

Reference54 articles.

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2. Candida Endophthalmitis

3. EndogenousCandidaendophthalmitis

4. Prospective Study of Candida Endophthalmitis in Hospitalized Patients With Candidemia

5. Mortality of Hospitalized Patients With Candida Endophthalmitis

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