Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C-Reference-Cited by-同舟云学术

Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C

Published:2003-04 Issue:7 Volume:77 Page:4435-4438
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Breslin Jamie J.¹,Mørk Irene²,Smith M. K.¹,Vogel Lotte K.²,Hemmila Erin M.¹,Bonavia Aurelio¹,Talbot Pierre J.³,Sjöström Hans²,Norén Ove²,Holmes Kathryn V.¹

Affiliation:

1. Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80262

2. Department of Medical Biochemistry and Genetics, University of Copenhagen, Copenhagen, Denmark

3. INRS-Institut Armand-Frappier, University of Quebec, Laval, Canada

Abstract

ABSTRACT Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37°C, but not 4°C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37°C that facilitate virus entry.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.7.4435-4438.2003

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