Quantitative Inhibition ofHaemophilus influenzaeby Trimethoprim/Sulfamethoxazole-Reference-Cited by-同舟云学术

Quantitative Inhibition ofHaemophilus influenzaeby Trimethoprim/Sulfamethoxazole

Published:1977-12 Issue:6 Volume:12 Page:649-654
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pelton Stephen I.¹¹¹²,Shurin Paul A.¹¹¹²,Klein Jerome O.¹¹¹²,Finland Maxwell¹¹¹²

Affiliation:

1. Channing Laboratory,1,2,3,4 and Department of Pediatrics1,2,3 Harvard Medical School; the Departments of Medical Microbiology and Pediatrics,1,2,3 Boston City Hospital1,2,3,4; and the Department of Pediatrics, Boston University School of Medicine,1,2,3 Boston, Massachusetts 02118

2. Channing Laboratory,1,2,3,4 and Department of Medicine4 Harvard Medical School; Boston City Hospital1,2,3,4; Boston, Massachusetts 02118

Abstract

We evaluated the inhibitory effect of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination, against 34 strains ofHaemophilus influenzae. Growth inhibition was determined after incubation for 18 h by comparing viable counts of cultures in drug-containing medium with corresponding counts of control cultures in drug-free medium. In a modified, thymidine-deficient Levinthal broth, the numbers of colony-forming units of all the isolates tested were reduced 100-fold or more by TMP/SMZ (1.25/25 μg/ml) as compared with growth without drug. Inhibition was significantly greater with TMP/SMZ than with either TMP or SMZ alone. Ampicillin-susceptible and ampicillin-resistant strains were equally susceptible to TMP/SMZ. Growth of nontypable strains was inhibited more than growth of type b organisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.12.6.649

Reference18 articles.

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2. Chloramphenicolresistant Haemophilus influenzae;Center for Disease Control.;Morbid. Mortal. Weekly Rep.,1976

3. In vitro resistance of Haemophilus influenzae to co-trimoxazole and trimethoprim;Cornere B. M.;N. Z. Med. J.,1975

4. Susceptibility of pneumococci and Haemophilus influenzae to antibacterial agents;Finland M.;Antimicrob. Agents Chemother.,1976

5. Fleiss J. L. 1973. Statistical methods for rates and proportions p. 85-87. John Wiley & Sons New York.

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