Pathogenesis of Rinderpest Virus Infection in Rabbits I. Clinical Signs, Immune Response, Histological Changes, and Virus Growth Patterns

Author:

Yamanouchi Kazuya1,Chino Fumitoshi1,Kobune Fumio1,Fukuda Akiko1,Yoshikawa Yasuhiro1

Affiliation:

1. Departments of Measles Virus and Pathology, National Institute of Health, Musashi-Murayama, Tokyo 190-12, Japan

Abstract

Rabbits were intravenously inoculated with an attenuated rinderpest virus (L strain), and general patterns of the disease were investigated. The rabbits developed fever with concomitant occurrence of diarrhea and lymphopenia. Early production of interferon was followed by a rise of neutralizing antibody. Histological examinations revealed an involvement of all of the lymphoid tissues, with primary lesions consisting of necrosis of the lymphoid follicles and formation of giant cells. Immunofluorescent examinations suggested that the virus growth was present in almost all of the lymphoid tissues. The possibility of application of this experimental system for the study of systemic infection by measles virus was discussed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference17 articles.

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2. Measles as an index of immunological function;Burnet F. M.;Lancet,1968

3. On the experimental infection with rinderpest virus in the rabbit;Fukusho K.;II. Pathology. Jap. J. Vet. Sci.,1940

4. Relationships among measles, canine distemper and rinderpest viruses;Imagawa D. T.;Progr. Med. Virol.,1968

5. Pathogenicity of rinderpest virus, original and attenuated, in various tissue cultures;Isogai I.;Jap. J. Infect. Dis.,1961

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