Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis-Reference-Cited by-同舟云学术

Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Miller Christopher R.¹,Dey Somrita¹,Smolenski Paula D.¹,Kulkarni Pushkar S.¹,Monk Jonathan M.²,Szubin Richard²,Sakoulas George³⁴,Berti Andrew D.¹⁵

Affiliation:

1. Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA

2. Department of Bioengineering, University of California at San Diego, La Jolla, California, USA

3. Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, California, USA

4. Sharp Memorial Hospital, San Diego, California, USA

5. Department of Biochemistry, Microbiology and Immunology, Wayne State University College of Medicine, Detroit, Michigan, USA

Abstract

We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR , and agrA . Pharmacokinetic simulations showed consistent activity of daptomycin plus beta-lactam against all subpopulations.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01593-19

Reference24 articles.

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2. Surgical Management of Infective Endocarditis Complicated by Embolic Stroke

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