Mobilization of tet (X4) by IS 1 Family Elements in Porcine Escherichia coli Isolates-Reference-Cited by-同舟云学术

Mobilization of tet (X4) by IS 1 Family Elements in Porcine Escherichia coli Isolates

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yu Runhao¹,Chen Zheng¹,Schwarz Stefan²^ORCID,Yao Hong¹,Du Xiang-Dang¹^ORCID

Affiliation:

1. College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, P. R. China

2. Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

Abstract

The dissemination mechanism of the high-level tigecycline resistance gene tet (X4) in porcine Escherichia coli was investigated. tet (X4) and other antimicrobial resistance genes were located on the plasmids p1919D3-1 and p1919D62-1 and flanked by two or three copies of IS 1 family elements, which can form one to three translocatable units (TUs). Using a reduced transposition model, IS 1A was experimentally demonstrated to mediate the transposition of tet (X4) from a suicide plasmid into the E. coli chromosome.

Funder

IRTSTHN

BMBF

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01597-21

Reference23 articles.

1. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae

2. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study