Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review-Reference-Cited by-同舟云学术

Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bai Anthony D.¹^ORCID,Komorowski Adam S.²^ORCID,Lo Carson K. L.¹,Tandon Pranav³,Li Xena X.¹²,Mokashi Vaibhav¹,Cvetkovic Anna¹,Findlater Aidan¹,Liang Laurel⁴,Loeb Mark¹,Mertz Dominik¹

Affiliation:

1. Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada

2. Division of Medical Microbiology, McMaster University, Hamilton, Ontario, Canada

3. Global Health Office, McMaster University, Hamilton, Ontario, Canada

4. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

Abstract

Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Our systematic review of 175 noninferiority antibiotic trials found these scenarios to be rare.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01597-20

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