Interspecies Dissemination of the bla Gene Encoding PER-1 Extended-Spectrum β-Lactamase

Author:

Bae Il Kwon1,Jang Sook Jin2,Kim Juwon1,Jeong Seok Hoon1,Cho Byungkyu3,Lee Kyungwon1

Affiliation:

1. Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Republic of Korea

2. Department of Laboratory Medicine, Chosun University College of Medicine, Gwangju, Republic of Korea

3. Department of Laboratory Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea

Abstract

ABSTRACT PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla PER-1 gene has never been reported in Klebsiella pneumoniae . Here, we studied interspecies dissemination of the bla PER-1 gene by horizontal transfer of Tn 1213 among Acinetobacter baumannii , Pseudomonas aeruginosa , and K. pneumoniae. In a K. pneumoniae clinical isolate, the bla PER-1 gene was located on a 150-kbp incompatibility group A/C plasmid.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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