Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis-Reference-Cited by-同舟云学术

Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barde François¹,Billaud Eliane²,Goldwirt Lauriane³,Horodyckid Catherine⁴,Jullien Vincent²,Lanternier Fanny¹⁵,Lesprit Philippe⁶,Limousin Lucie⁷,Cohen Jérémie F.¹^ORCID,Lortholary Olivier¹⁵

Affiliation:

1. Necker-Pasteur Center for Infectious Diseases and Tropical Medicine, Necker-Enfants Malades Hospital, AP-HP, Paris Descartes University, Paris, France

2. Laboratory of Pharmacology and Toxicology, European Hospital Georges Pompidou, AP-HP, Paris Descartes University, Paris, France

3. Department of Pharmacology, Saint-Louis Hospital, AP-HP, Paris Diderot University, Paris, France

4. Department of Neurosurgery, Foch Hospital, Suresnes, France

5. Institut Pasteur, Molecular Mycology Unit, National Reference Center for Invasive Mycoses and Antifungals, CNRS UMR 2000, Paris, France

6. Department of Clinical Biology, Foch Hospital, Suresnes, France

7. Department of Microbiology, Foch Hospital, Suresnes, France

Abstract

Posaconazole diffusion has been documented in various organs, which contrasts with the scarce data available for the human central nervous system (CNS). We analyzed posaconazole concentrations in plasma and multiple CNS specimens taken from a patient who received posaconazole because of cerebral phaeohyphomycosis. Low posaconazole concentrations were obtained in CNS specimens, with sample-to-plasma ratios between 5% and 22%.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01184-19

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