A Recombinant Adenovirus Expressing Ovine Interferon Tau Prevents Influenza Virus-Induced Lethality in Mice-Reference-Cited by-同舟云学术

A Recombinant Adenovirus Expressing Ovine Interferon Tau Prevents Influenza Virus-Induced Lethality in Mice

Published:2016-04 Issue:7 Volume:90 Page:3783-3788
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Martín V.¹,Pascual E.¹,Avia M.¹,Rangel G.¹,de Molina A.²,Alejo A.¹,Sevilla N.¹

Affiliation:

1. Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain

2. Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

Abstract

ABSTRACT Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and a broad host range in vivo . We report the generation of a nonreplicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model, we showed that single-dose intranasal administration of recombinant Ad5-IFN-τ can effectively prevent lethality and disease induced by highly virulent hv-PR8 influenza virus by activating the interferon response and preventing viral replication.

Funder

Ministerio de Ciencia e Innovacion

Comunidad de Madrid

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.03258-15

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