Clinical Evaluation of a Real-Time PCR Assay for Simultaneous Detection of Helicobacter pylori and Genotypic Markers of Clarithromycin Resistance Directly from Stool-Reference-Cited by-同舟云学术

Clinical Evaluation of a Real-Time PCR Assay for Simultaneous Detection of Helicobacter pylori and Genotypic Markers of Clarithromycin Resistance Directly from Stool

Published:2021-04-20 Issue:5 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Marrero Rolon Rebecca¹²,Cunningham Scott A.²,Mandrekar Jayawant N.³,Polo Erin T.⁴,Patel Robin²⁵^ORCID

Affiliation:

1. Department of Pathology, Clinical Microbiology, Montefiore Medical Center, Bronx, New York, USA

2. Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA

3. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA

4. TIB MOLBIOL, Adelphia, New Jersery, USA

5. Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA

Abstract

Helicobacter pylori infection is mainly diagnosed noninvasively, with susceptibility testing traditionally requiring endoscopy. Treatment is empirical, with clarithromycin-based triple therapy recommended where resistance rates are below 15%. Rising rates of clarithromycin resistance, resulting in high therapy failure rates, are seen worldwide, but U.S. data are limited.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.03040-20

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