Inhibitory effects of polyethers on human immunodeficiency virus replication-Reference-Cited by-同舟云学术

Inhibitory effects of polyethers on human immunodeficiency virus replication

Published:1992-02 Issue:2 Volume:36 Page:492-494
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nakamura M¹,Kunimoto S¹,Takahashi Y¹,Naganawa H¹,Sakaue M¹,Inoue S¹,Ohno T¹,Takeuchi T¹

Affiliation:

1. Department of Microbiology, Jikei University School of Medicine, Tokyo, Japan.

Abstract

We examined the inhibitory activities of 10 polyether antibiotics on human immunodeficiency virus (HIV) type 1. These compounds caused concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. The ratio of 50% effective concentrations for cellular cytotoxicity (MTT assay) to antiviral activity (reverse transcriptase assay) was over 5. Anti-HIV activity was also observed in cultures of monocytic lineage U937 cells chronically infected with HIV.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.36.2.492

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